國家理論科學研究中心 & 教育部國家講座聯合演講: Spatial Periodicities in Chromosomeal Gene Expression Revealed by Spec
Abstract:
The extensive effort in the analysis of gene expression over the last
decade has been almost uniformly focused on the genome-wide gene
expression and has largely ignored the fundamental fact that every gene
has a specific chromosome location. We propose a novel method of spectral
analysis for detecting hidden periodicities in gene expression signals
ordered along the length of each chromosome. The method is based on a
consistent estimator of the discrete spectrum of asymptotically stationary
stochastic processes previously discovered by the author for solving an
entirely different problem. Using this method, we have discovered that
each chromosome in rodents and humans has a unique, stable periodic
pattern of gene expression insensitive to local genomic alterations. The
estimated periods and amplitudes are identical for the genes located on
the positive and negative DNA strands. The uncovered spatial periodicities
in gene expression were found to be tissue-specific. Importantly, large
differences in chromosomal gene expression in humans were observed between
two normal tissues (brain and mammary gland) and their malignant
counterparts (glioma and breast cancer). However, these differences are
localized only on some of the chromosomes. While molecular mechanisms of
chromosome-specific periodicities in gene expression have yet to be
unraveled, the discovered periodic patterns of gene expression may have
applications as diagnostic and prognostic tools in medicine.
2012-02-29 15:00 ~ 2012-02-29 16:00
Prof. Leonid Hanin (Idaho State University and Georgia Institute of Technology, USA)